3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561678Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561678
ClC1C=CC(C(C2CC2)C2C3C(=C(CSC)C([F:18])=CC=3)NC=2)=CC=1.[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH:42]=[CH:43][CH:44]=3)[NH:39][CH:38]=2)([CH:34]2[CH2:36][CH2:35]2)C)=[CH:28][CH:27]=1>>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([CH:32]([CH:34]2[CH2:36][CH2:35]2)[C:37]2[C:45]3[C:40](=[C:41]([CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[C:42]([F:18])=[CH:43][CH:44]=3)[NH:39][CH:38]=2)=[CH:28][CH:27]=1

Komponenten

3

Edukt 2

HCID 583923763-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Produkt 1

HCID 592939413-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfonyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 238 mg (0.66 mmol) of the compound from Example 234 in analogy to the synthesis of the compound from Example 209. 144 mg (55% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom144 mg (55% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-709d663b02ad427e9810a59d429620d6
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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