(3-Chloro-4-fluorophenyl)(4-chlorophenyl)methanol → 3-[(3-Chloro-4-fluorophenyl)(4-chlorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561701Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561701
[CH3:1][S:2][CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2.[Cl:13][C:14]1[CH:15]=[C:16]([CH:21]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)O)[CH:17]=[CH:18][C:19]=1[F:20].FC1C=CC(C(C2C=CC(F)=CC=2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1>>[Cl:13][C:14]1[CH:15]=[C:16]([CH:21]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[C:9]2[C:8]3[C:12](=[C:4]([CH2:3][S:2][CH3:1])[CH:5]=[CH:6][CH:7]=3)[NH:11][CH:10]=2)[CH:17]=[CH:18][C:19]=1[F:20]

Komponenten

4

Edukt 3

HCID 2758103(3-Chloro-4-fluorophenyl)(4-chlorophenyl)methanolHCID 583921273-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583921877-[(Methylsulfanyl)methyl]-1H-indole

Produkt 1

HCID 583922413-[(3-Chloro-4-fluorophenyl)(4-chlorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 750 mg (4.23 mmol) of the compound from Example 8A and 1.15 g (4.23 mmol) of the compound from Example 177A in analogy to the synthesis of the compound from Example 278. 483 mg (26% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom483 mg (26% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-624db7f2ef884e08b61626cafb8e9085
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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