(4-Chlorophenyl)(4-fluorophenyl)methanol → 3-[(4-Chlorophenyl)(4-fluorophenyl)methyl]-5-fluoro-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561708Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561708
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11][S:12][CH3:13])[CH:10]=1)[NH:7][CH:6]=[CH:5]2.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)O)=[CH:17][CH:16]=1.FC1C=CC(C(C2C=CC(F)=CC=2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([CH:21]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[C:5]2[C:4]3[C:8](=[C:9]([CH2:11][S:12][CH3:13])[CH:10]=[C:2]([F:1])[CH:3]=3)[NH:7][CH:6]=2)=[CH:19][CH:20]=1

Komponenten

4

Edukt 3

HCID 12634874(4-Chlorophenyl)(4-fluorophenyl)methanolHCID 583921273-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583922275-Fluoro-7-[(methylsulfanyl)methyl]-1H-indole

Produkt 1

HCID 583921723-[(4-Chlorophenyl)(4-fluorophenyl)methyl]-5-fluoro-7-[(methylsulfanyl)methyl]-1H-indole

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

The title compound was prepared starting from 500 mg (2.56 mmol) of the compound from Example 11A and 667 mg (2.56 mmol) of the compound from Example 81A in analogy to the synthesis of the compound from Example 278. A difference was that stirring at 80° C. was for only 4 h. 535 mg (50% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom535 mg (50% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-96b97a45989947df83e8d72184099e7e
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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