3-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → 5-Fluoro-3-[(4-fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

HRID 561709Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561709
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11][S:12][CH3:13])[CH:10]=1)[NH:7][CH:6]=[CH:5]2.[F:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)O)=[C:17]([CH3:30])[CH:16]=1.FC1C=CC(C(C2C=CC(F)=CC=2)C2C3C(=C(CSC)C=CC=3)NC=2)=CC=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11][S:12][CH3:13])[CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:21]([C:18]1[CH:19]=[CH:20][C:15]([F:14])=[CH:16][C:17]=1[CH3:30])[C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1

Komponenten

4

Edukt 3

HCID 583921273-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 58392149(4-Fluoro-2-methylphenyl)(4-fluorophenyl)methanolHCID 583922275-Fluoro-7-[(methylsulfanyl)methyl]-1H-indole

Produkt 1

HCID 583922205-Fluoro-3-[(4-fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

The title compound was prepared starting from 500 mg (2.56 mmol) of the compound from Example 11A and 733 mg (2.56 mmol) of the compound from Example 82A in analogy to the synthesis of the compound from Example 278. A difference was that stirring at 80° C. was for only 4 h. 428 mg (39% of theory) of the target compound were obtained.

Aufarbeitung

  1. custom428 mg (39% of theory) of the target compound were obtained

Quellen und Nachweise

ORD-Eintrag
ord-509fd0276c924687a3c4d8e28608265c
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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