3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → 4-[(4-Fluorophenyl){7-[(methylsulfinyl)methyl]-1H-indol-3-yl}methyl]benzonitrile

HRID 561712Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561712
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:17]2[C:25]3[C:20](=[C:21]([CH2:26][S:27][CH3:28])[CH:22]=[CH:23][CH:24]=3)[NH:19][CH:18]=2)[C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.ClC1C=CC(C(C2C=CC(Cl)=CC=2)C2C3C(=C(CS(C)=[O:48])C=CC=3)NC=2)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:17]2[C:25]3[C:20](=[C:21]([CH2:26][S:27]([CH3:28])=[O:48])[CH:22]=[CH:23][CH:24]=3)[NH:19][CH:18]=2)[C:9]2[CH:10]=[CH:11][C:12]([C:13]#[N:14])=[CH:15][CH:16]=2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 583921253-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indoleHCID 670008524-[(4-Fluorophenyl){7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]benzonitrile

Produkt 1

HCID 670014734-[(4-Fluorophenyl){7-[(methylsulfinyl)methyl]-1H-indol-3-yl}methyl]benzonitrile

Versuchsvorschrift

The title compound was prepared starting from 60 mg (0.16 mmol) of the compound from Example 280 in analogy to the synthesis of the compound from Example 296. 61 mg (98% of theory) of the target compound were obtained as mixture of diastereomers.

Aufarbeitung

  1. custom61 mg (98% of theory) of the target compound were obtained as mixture of diastereomers

Quellen und Nachweise

ORD-Eintrag
ord-7bdcde3672c1464a9e441b3e286e23a5
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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