3-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole → 3-[(4-Chloro-2-fluorophenyl)(4-fluoro-2-methylphenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole

HRID 561717Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561717
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[CH3:28])[C:9]2[C:17]3[C:12](=[C:13]([CH2:18][S:19][CH3:20])[CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)=[C:4]([F:29])[CH:3]=1.ClC1C=CC(C(C2C=CC(Cl)=CC=2)C2C3C(=C(CS(C)=[O:49])C=CC=3)NC=2)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[CH3:28])[C:9]2[C:17]3[C:12](=[C:13]([CH2:18][S:19]([CH3:20])=[O:49])[CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)=[C:4]([F:29])[CH:3]=1

Komponenten

3

Edukt 2

HCID 583921253-[Bis(4-chlorophenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indoleHCID 583921623-[(4-Chloro-2-fluorophenyl)(4-fluoro-2-methylphenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole

Produkt 1

HCID 583921393-[(4-Chloro-2-fluorophenyl)(4-fluoro-2-methylphenyl)methyl]-7-[(methylsulfinyl)methyl]-1H-indole

Versuchsvorschrift

The title compound was prepared starting from 100 mg (0.23 mmol) of the compound from Example 287 in analogy to the synthesis of the compound from Example 296. 99 mg (95% of theory) of the target compound were obtained as mixture of diastereomers.

Aufarbeitung

  1. custom99 mg (95% of theory) of the target compound were obtained as mixture of diastereomers

Quellen und Nachweise

ORD-Eintrag
ord-0db01dd20abb48cfbb10720c86f74c33
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063234B2

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