Ethyl Acetate → [4-(Methanesulfonylaminocarbonyl)butyl]triphenylphosphonium bromide

Beteiligte Stoffe

Reaktionsschritte

A stirring mixture consisting of triphenylphosphine (13.2 g, 24.4 mmol) and 5-bromo-N-(methylsulfonyl)pentanamide (prepared in Step A, 5.55 g, 21.5 mmol) in xylene (15 mL) was brought to reflux for 4 hours. Subsequently, ethyl acetate was added to the hot reaction mixture and stirring was continued for the next 15 minutes. The crude product was isolated from acetone-ethyl acetate to afford the title intermediate (8.68 g, 78%); melting point 189-190° C.

Herkunft & Nachweise