Potassium Carbonate → 2-fluoro-4-nitro-N-(2-(piperidin-1-yl)ethyl)aniline

HRID 56187

Reaktionsgleichung

Reaktionsgleichung von HRID 56187
[N:1]1([CH2:7][CH2:8][NH2:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].F[C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][C:18]=1[F:26]>CC(C)=O>[F:26][C:18]1[CH:19]=[C:20]([N+:23]([O-:25])=[O:24])[CH:21]=[CH:22][C:17]=1[NH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 33944N-(2-Aminoethyl)piperidineHCID 1230531,2-Difluoro-4-nitrobenzene

Produkt 1

HCID 523235752-fluoro-4-nitro-N-(2-(piperidin-1-yl)ethyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a suspension of 2-(piperidin-1-yl)ethanamine (0.90 g, 7.02 mmol) and K2CO3 (0.97 g, 7.02 mmol) in acetone (30 mL) was added 1,2-difluoro-4-nitrobenzene (1.11 g, 6.98 mmol) in one portion in an ice bath and the mixture was refluxed overnight, cooled to rt and filtered. The filtrate was concentrated in vacuo to give the crude product, which was used for next step without further purification.

Aufarbeitung

  1. temperaturethe mixture was refluxed overnight
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-21db24e4e1534aff9214e05e442c933c
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434695B2

Verknüpfte Notizen

Wird geladen…