1-(2-Fluoro-4-iodo-phenyl)-ethanol → 2'-Fluoro-4'-iodoacetophenone

HRID 561962Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 561962
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[CH:9]([OH:11])[CH3:10]>ClCCl.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10]

Komponenten

4

Edukt 1

HCID 534154531-(2-Fluoro-4-iodo-phenyl)-ethanol

Produkt 1

HCID 534154542'-Fluoro-4'-iodoacetophenoneAusbeute 91,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 1-(2-fluoro-4-iodo-phenyl)-ethanol (15.50 g, 58.26 mmol) in dichloromethane (250 mL) was added manganese dioxide (101.26 g, 1.17 mole) and the reaction mixture was heated to reflux for 24 hours. The reaction mixture was cooled, filtered through a pad of celite coated with a thin layer of silica gel and concentrated in vacuo to give 1-(2-fluoro-4-iodo-phenyl)-ethanone (14.04 g, 91%).

Aufarbeitung

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 24 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationfiltered through a pad of celite coated with a thin layer of silica gel
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b0979d46b68d4c4dbb22e9005ec959b9
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063085B2

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