Hydrochloric Acid → 5-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide hydrochloride

HRID 562029

Reaktionsgleichung

Reaktionsgleichung von HRID 562029
[ClH:1].[NH2:2][C:3]([C:5]1[CH:6]=[C:7]([Br:27])[CH:8]=[C:9]2[C:13]=1[NH:12][CH:11]=[C:10]2[CH:14]1[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]1)=[O:4]>O1CCOCC1.CO>[ClH:1].[Br:27][C:7]1[CH:8]=[C:9]2[C:13](=[C:5]([C:3]([NH2:2])=[O:4])[CH:6]=1)[NH:12][CH:11]=[C:10]2[CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 59600660tert-butyl 4-(5-bromo-7-carbamoyl-1H-indol-3-yl)piperidine-1-carboxylate

Produkt 1

HCID 667232845-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A 4M solution of HCl in dioxane (194 mL) was added to a solution of 1,1-dimethylethyl 4-[7-(aminocarbonyl)-5-bromo-1H-indol-3-yl]-1-piperidinecarboxylate (10 g, 23.7 mmol) in methanol (50 mL). The reaction mixture was stirred at room temperature for 4 hours, and the solvent was evaporated under reduced pressure to give the title compound (9.5 g), which was used in the next step without further purification.

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e3c06bea0b0c42e3b1cc8fcc7ab25cad
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063071B2

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