Ammonia → (Z)-3-amino-N-(3-cyano-4-(dihexylamino)phenyl)but-2-enamide

HRID 56208Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 56208
[C:1]([C:3]1[CH:4]=[C:5]([NH:22][C:23](=[O:28])[CH2:24][C:25](=O)[CH3:26])[CH:6]=[CH:7][C:8]=1[N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])#[N:2].[NH3:29]>CO>[NH2:29]/[C:25](/[CH3:26])=[CH:24]\[C:23]([NH:22][C:5]1[CH:6]=[CH:7][C:8]([N:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[C:3]([C:1]#[N:2])[CH:4]=1)=[O:28]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 90023598N-(3-cyano-4-(dihexylamino)phenyl)-3-oxobutanamide

Produkt 1

HCID 90022969(Z)-3-amino-N-(3-cyano-4-(dihexylamino)phenyl)but-2-enamideAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of N-(3-cyano-4-(dihexylamino)phenyl)-3-oxobutanamide (1.47 g, 3.81 mmol), MeOH (15 mL) and ammonia (15 mL) was stirred at rt overnight. The mixture was concentrated in vacuo to give the title compound as black oil (1.30 g, 88%).

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-af8d51602c5843c0afb91c84da09b43c
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434695B2

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