HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(5-Bromothiophen-2-yl)piperazine → 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[4-(2-piperazinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(5-Bromothiophen-2-yl)piperazine | HCID 19763606 | — |
| Edukt | 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[5-(2-piperazinyl)-2-thienyl]-1H-indole-7-carboxamide trifluoroacetate | HCID 66723302 | — |
| Produkt | 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[4-(2-piperazinyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate | HCID 66722948 | 25,9% |
Reaktionsschritte
The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[5-(2-piperazinyl)-2-thienyl]-1H-indole-7-carboxamide trifluoroacetate, substituting 2-(4-bromophenyl)piperazine (94 mg, 0.39 mmol) for 2-(5-bromo-2-thienyl)piperazine to afford 20.5 mg of the title compound (25.9%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063071B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-25819822f188489b9d71177f0c149c92 |
| Quellennotiz | uspto-grants-2011_11 |