HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(S)-(+)-Tetrahydrofurfurylamine → 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-fluoro-5-{[(1-methylpropyl)amino]methyl}phenyl)-1H-indole-7-carboxamide trifluoroacetate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (S)-(+)-Tetrahydrofurfurylamine | HCID 641530 | — |
| Edukt | 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(2S)-tetrahydro-2-furanylmethyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate | HCID 66723136 | — |
| Produkt | 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-fluoro-5-{[(1-methylpropyl)amino]methyl}phenyl)-1H-indole-7-carboxamide trifluoroacetate | HCID 66722915 | 50,6% |
Reaktionsschritte
The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-fluoro-5-({[(2S)-tetrahydro-2-furanylmethyl]amino}methyl)phenyl]-1H-indole-7-carboxamide trifluoroacetate, substituting 2-butanamine (37 mg, 0.525 mmol) for 1-[(2S)-tetrahydro-2-furanyl]methanamine to afford 27.7 mg of the title compound (50.6%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063071B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-a8258663e960445cbbebf80e0e8a22ea |
| Quellennotiz | uspto-grants-2011_11 |