HCID 66723115, Verbindung → HCID 57732742, Verbindung

HRID 562290Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 562290
[CH2:1]([S:3]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[C:16]([C:35]([NH2:37])=[O:36])[CH:17]=[C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][NH:28][C:29](=[O:34])CCCC)[CH:22]=4)[CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])=[O:4])[CH3:2].CC1(C)C(C)(C)OB(C2C=[C:48]([CH2:52][NH:53][C:54](=[O:59])[CH2:55]CCC)[CH:49]=[CH:50][CH:51]=2)O1>>[C:54]([N:53]1[CH2:52][CH2:48][CH:49]([C:29]([NH:28][CH2:27][C:23]2[CH:22]=[C:21]([C:18]3[CH:19]=[C:20]4[C:15](=[C:16]([C:35]([NH2:37])=[O:36])[CH:17]=3)[NH:14][CH:13]=[C:12]4[CH:9]3[CH2:8][CH2:7][N:6]([S:3]([CH2:1][CH3:2])(=[O:4])=[O:5])[CH2:11][CH2:10]3)[CH:26]=[CH:25][CH:24]=2)=[O:34])[CH2:50][CH2:51]1)(=[O:59])[CH3:55]

Komponenten

3

Edukt 2

HCID 66723115HCID 66723115, VerbindungHCID 66723251HCID 66723251, Verbindung

Produkt 1

HCID 57732742HCID 57732742, Verbindung

Versuchsvorschrift

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-{3-[(pentanoylamino)methyl]phenyl}-1H-indole-7-carboxamide substituting 1-acetyl-N-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}-4-piperidinecarboxamide (56 mg, 0.144 mmol) for N-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}pentanamide. Compound was purified by Gilson Preparatory HPLC to give the title compound.

Aufarbeitung

  1. customThe title compound was prepared
  2. customCompound was purified by Gilson Preparatory HPLC

Quellen und Nachweise

ORD-Eintrag
ord-0f8a3080a7a34c618f71b8394ed12647
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063071B2

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