HCID 66723115, Verbindung → HCID 57732634, Verbindung

HRID 562291Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 562291
[CH2:1]([S:3]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[C:16]([C:35]([NH2:37])=[O:36])[CH:17]=[C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][NH:28][C:29](=[O:34])[CH2:30][CH2:31][CH2:32][CH3:33])[CH:22]=4)[CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])=[O:4])[CH3:2].CC1(C)C(C)(C)OB(C2C=C([CH2:52][NH:53]C(=O)CCCC)C=CC=2)O1>>[CH2:1]([S:3]([N:6]1[CH2:7][CH2:8][CH:9]([C:12]2[C:20]3[C:15](=[C:16]([C:35]([NH2:37])=[O:36])[CH:17]=[C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][NH:28][C:29]([C:30]5[N:53]([CH3:52])[CH:33]=[CH:32][CH:31]=5)=[O:34])[CH:22]=4)[CH:19]=3)[NH:14][CH:13]=2)[CH2:10][CH2:11]1)(=[O:5])=[O:4])[CH3:2]

Komponenten

3

Edukt 2

HCID 66723115HCID 66723115, VerbindungHCID 66723251HCID 66723251, Verbindung

Produkt 1

HCID 57732634HCID 57732634, Verbindung

Versuchsvorschrift

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-{3-[(pentanoylamino)methyl]phenyl}-1H-indole-7-carboxamide substituting 1-methyl-N-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}-1H-pyrrole-2-carboxamide (49 mg, 0.144 mmol) for N-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}pentanamide. Compound was purified by Gilson Preparatory HPLC to give the title compound.

Aufarbeitung

  1. customThe title compound was prepared
  2. customCompound was purified by Gilson Preparatory HPLC

Quellen und Nachweise

ORD-Eintrag
ord-a8596be7cdec45be9bdf100f66c7c3fb
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063071B2

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