Dimethylformamide diethylacetal → Ethyl 3-(N,N-dimethylamino)-2-(1H-imidazol-1-yl)acrylate

HRID 562447Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 562447
[N:1]1([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:5]=[CH:4][N:3]=[CH:2]1.C(O[CH:15](OCC)[N:16]([CH3:18])[CH3:17])C>>[CH3:15][N:16]([CH:18]=[C:6]([N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH3:17]

Komponenten

3

Edukt 2

HCID 70913Dimethylformamide diethylacetalHCID 3798501ethyl 2-(1H-imidazol-1-yl)acetate

Produkt 1

HCID 66726242Ethyl 3-(N,N-dimethylamino)-2-(1H-imidazol-1-yl)acrylate

Versuchsvorschrift

38.0 g (244.9 mmol) of the compound from Example 3A are stirred in 126 ml (108.1 g, 734.7 mmol) of N,N-dimethylformamide diethyl acetal at a bath temperature of 90° C. for 16 h. After cooling, the mixture is concentrated under reduced pressure, the residue is stirred with diisopropyl ether and the solid is filtered off and finally washed with diisopropyl ether. Yield: 49.0 g (95% of theory)

Aufarbeitung

  1. temperatureAfter cooling
  2. concentrationthe mixture is concentrated under reduced pressure
  3. filtrationthe solid is filtered off
  4. washfinally washed with diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-f25bccf5087346a5946a6563ea7435c9
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067407B2

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