Imatinib → Imatinib Mesylate

HRID 562559

Reaktionsgleichung

Reaktionsgleichung von HRID 562559
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([CH2:30][N:31]3[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]3)=[CH:28][CH:29]=2)=[O:23])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40].COC(O)C.C(OC(O)C)C>[N+](C)([O-])=O.C(#N)C.C1(=O)OC(C)CO1.CN1CCCC1=O.CO>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([CH2:30][N:31]3[CH2:32][CH2:33][N:34]([CH3:37])[CH2:35][CH2:36]3)=[CH:26][CH:25]=2)=[O:23])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40]

Komponenten

10

Edukt 4

HCID 5291ImatinibHCID 6395Methanesulfonic AcidHCID 30156371-MethoxyethanolHCID 101298981-Ethoxyethanol

Produkt 1

HCID 123596Imatinib Mesylate

Reagenzien, Katalysatoren, Lösungsmittel 5

HCID 887MethanolLösungsmittelHCID 6342AcetonitrileLösungsmittelHCID 6375NitromethaneLösungsmittelHCID 7924Propylene CarbonateLösungsmittelHCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

Alternatively, the solution may be prepared by admixing imatinib base, methanesulfonic acid and a solvent selected from the group consisting of: methanol, methoxyethanol or ethoxyethanol, N-methylpyrrolidone, propylene carbonate, acetonitrile, nitromethane to obtain a mixture; and heating the mixture to obtain an imatinib mesylate solution. Heating the mixture to obtain an imatinib mesylate solution is preferably to a temperature of about 20° C. to about 85° C., more preferably of about 60° C. to about 80° C. Preferably, the obtained solution is further cooled to a temperature of about 20° C. to about 0° C. prior to the addition of the anti-solvent. Preferably the solution of imatinib mesylate is gradually added to the anti-solvent under stirring. Preferably, the solution of imatinib mesylate is added to an excess of anti-solvent.

Aufarbeitung

  1. customAlternatively, the solution may be prepared
  2. customto obtain a mixture
  3. temperatureand heating the mixture

Quellen und Nachweise

ORD-Eintrag
ord-c47d0b859c424b8288f13b2b12baf475
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067421B2

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