3-Fluorophenol → Ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate

HRID 56294

Reaktionsgleichung

Reaktionsgleichung von HRID 56294
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Br[C:10]([F:17])([F:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12].C([O-])([O-])=O.[K+].[K+]>CO>[F:16][C:10]([F:17])([O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Komponenten

5

Edukt 3

HCID 97433-FluorophenolHCID 11430Potassium CarbonateHCID 69585Ethyl bromodifluoroacetate

Produkt 1

HCID 66455005Ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A mixture of 3-fluorophenol (2.24 g, 20.0 mmol), ethyl 2-bromo-2,2-difluoroacetate (8.12 g, 40.0 mmol) and K2CO3 (6.91 g, 50.0 mmol) in MeOH (20 mL) was stirred at 70° C. overnight. It was then cooled to rt and filtered and the filtrate was concentrated in vacuo to give the title compound, which was used for next step without further purification.

Aufarbeitung

  1. temperatureIt was then cooled to rt
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-47bd33ea822e493bb4ab17fa47d0f8ef
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434695B2

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