Ibuprofen, (+-)- → HCID 178440860, Verbindung

HRID 563048

Reaktionsgleichung

Reaktionsgleichung von HRID 563048
[CH:1]1[S:5][C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[N:3][C:2]=1[CH2:10][S:11][CH2:12][CH2:13][C:14]([NH:16][S:17]([NH2:20])(=[O:19])=[O:18])=[NH:15].[OH:21][C:22]([CH:24]([C:26]1[CH:35]=[CH:34][C:29]([CH2:30][CH:31]([CH3:33])[CH3:32])=[CH:28][CH:27]=1)[CH3:25])=[O:23]>>[OH:23][C:22]([CH:24]([C:26]1[CH:27]=[CH:28][C:29]([CH2:30][CH:31]([CH3:32])[CH3:33])=[CH:34][CH:35]=1)[CH3:25])=[O:21].[CH:1]1[S:5][C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[N:3][C:2]=1[CH2:10][S:11][CH2:12][CH2:13][C:14]([NH:16][S:17]([NH2:20])(=[O:19])=[O:18])=[NH:15]

Komponenten

3

Edukt 2

HCID 3672Ibuprofen, (+-)-HCID 178418935HCID 178418935, Verbindung

Produkt 1

HCID 178440860HCID 178440860, Verbindung

Versuchsvorschrift

The famotidine granules are mixed with ibuprofen granules (prepared as described in Table 27, infra) in a proportion that results in an ibuprofen:famotidine (800:26.6) mixture. Colliodal silicon dioxide, croscarmellose, silicified microcrystalline cellulose, and magnesium stearate are added to the ibuprofen-famotidine mixture, and the resulting mixture is compressed into tablets containing 800 mg ibuprofen and 26.6 mg famotidine (calculated weight).

Quellen und Nachweise

ORD-Eintrag
ord-3523603347704f0dae417da10e8f218f
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067451B2

Verknüpfte Notizen

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