Hydrochloric Acid → 3-(1-(4-fluorophenyl)-6-isopropyl-1H-indazol-5-yl)-2,2-dimethylpropanoic acid

HRID 563375

Reaktionsgleichung

Reaktionsgleichung von HRID 563375
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH2:20][C:21]([CH3:27])([CH3:26])[C:22]([O:24]C)=[O:23])=[C:14]([CH:17]([CH3:19])[CH3:18])[CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.Cl>[OH-].[Na+].CO.CS(C)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH2:20][C:21]([CH3:27])([CH3:26])[C:22]([OH:24])=[O:23])=[C:14]([CH:17]([CH3:19])[CH3:18])[CH:15]=3)[CH:10]=[N:9]2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67005600methyl 3-(1-(4-fluorophenyl)-6-isopropyl-1H-indazol-5-yl)-2,2-dimethylpropanoate

Produkt 1

HCID 670057273-(1-(4-fluorophenyl)-6-isopropyl-1H-indazol-5-yl)-2,2-dimethylpropanoic acidAusbeute 99,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 86640187NaOH MeOH DMSOLösungsmittel

Versuchsvorschrift

Methyl 3-(1-(4-fluorophenyl)-6-isopropyl-1H-indazol-5-yl)-2,2-dimethylpropanoate (87 mg, 0.236 mmol) was heated to 100 C overnight in a mixture of 2 M NaOH/MeOH/DMSO (1:1:1). The next day, the reaction was cooled, acidified to pH 5 with HCl and extracted 2×EtOAc. The organic layers were washed with water×2, dried over MgSO4, filtered, and concentrated in vacuo to give 83 mg (99% yield) of acid 3-(1-(4-fluorophenyl)-6-isopropyl-1H-indazol-5-yl)-2,2-dimethylpropanoic acid. MS found: (M+H)+=355.

Aufarbeitung

  1. temperatureThe next day, the reaction was cooled
  2. extractionextracted 2×EtOAc
  3. washThe organic layers were washed with water×2
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e0c7ddb8b72b48c086f17d9faca4bf5c
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067447B2

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