1-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one dihydrochloride → HCID 178439302, Verbindung

HRID 56347

Reaktionsgleichung

Reaktionsgleichung von HRID 56347
[CH:1]([C:4]1[CH:8]=[C:7]([C:9]([OH:11])=O)[NH:6][N:5]=1)([CH3:3])[CH3:2].Cl.Cl.[F:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](=[O:29])[CH2:22][N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](=[O:29])[CH2:22][N:23]2[CH2:24][CH2:25][N:26]([C:9]([C:7]3[NH:6][N:5]=[C:4]([CH:1]([CH3:2])[CH3:3])[CH:8]=3)=[O:11])[CH2:27][CH2:28]2)=[CH:17][CH:16]=1

Komponenten

3

Edukt 2

HCID 429337161-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one dihydrochlorideHCID 178439321HCID 178439321, Verbindung

Produkt 1

HCID 178439302HCID 178439302, VerbindungAusbeute 75,7 %

Versuchsvorschrift

The title compound was prepared in a similar manner as described in Example 1.2, using 3-isopropyl-1H-pyrazole-5-carboxylic acid (23.1 mg), and 1-(4-fluorophenyl)-2-(piperazin-1-yl)ethanone dihydrochloride (29.5 mg) as starting materials, to afford the title compound (27.1 mg) as a white solid. Exact mass calculated for C19H23FN4O2: 358.2. Found: LCMS m/z=359.3 (M+H+).

Aufarbeitung

  1. customThe title compound was prepared in a similar manner

Quellen und Nachweise

ORD-Eintrag
ord-e46949253468427a9f842e212b3d93d3
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434692B2

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