3-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acid → HCID 24810976, Verbindung

HRID 56350

Reaktionsgleichung

Reaktionsgleichung von HRID 56350
[C:1]([C:5]1[CH:9]=[C:8]([C:10]([OH:12])=O)[N:7]([CH3:13])[N:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:23](=[O:31])[CH2:24][N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:19][CH:18]=1>>[C:1]([C:5]1[CH:9]=[C:8]([C:10]([N:28]2[CH2:27][CH2:26][N:25]([CH2:24][C:23]([C:20]3[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=3)=[O:31])[CH2:30][CH2:29]2)=[O:12])[N:7]([CH3:13])[N:6]=1)([CH3:2])([CH3:3])[CH3:4]

Komponenten

3

Edukt 2

HCID 7205293-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acidHCID 429337161-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one dihydrochloride

Produkt 1

HCID 24810976HCID 24810976, VerbindungAusbeute 91,9 %

Versuchsvorschrift

The title compound was prepared in a similar manner as described in Example 1.2, using 3-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acid (27.3 mg), and 1-(4-fluorophenyl)-2-(piperazin-1-yl)ethanone dihydrochloride (29.5 mg) as starting materials, to afford the title compound (35.5 mg) as a yellow solid. Exact mass calculated for C21H27FN4O2: 386.2. Found: LCMS m/z=387.5 (M+H+).

Aufarbeitung

  1. customThe title compound was prepared in a similar manner

Quellen und Nachweise

ORD-Eintrag
ord-96434d945b19418f81d8c3ae2719b1d7
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434692B2

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