Hydrochloric Acid → methyl 2-(5-bromo-2-fluorophenyl)acetate

HRID 563789Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 563789
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:12])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1.Cl.[CH3:14]O>O1CCOCC1>[CH3:14][O:10][C:9](=[O:11])[CH2:8][C:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=1[F:12]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 35846902-(5-Bromo-2-fluorophenyl)acetic acid

Produkt 1

HCID 58148958methyl 2-(5-bromo-2-fluorophenyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a solution of (5-bromo-2-fluoro-phenyl)-acetic acid (2.3 mmol) in MeOH (15 mL) was added 4N HCl in 1,4-dioxane (2 mL), and the reaction was stirred at 90° C. for 2 hours. The mixture was concentrated, and the residue was purified by silica gel chromatography to give the title compound.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-57f0b91e6881458fa8a9ff486027b708
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067445B2

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