Chlorosuccinimide → 2-chloro-2-methylthio-N-(2-methylpent-3-yn-2-yl)acetamide

HRID 563888Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 563888
[CH3:1][S:2][CH2:3][C:4]([NH:6][C:7]([CH3:12])([C:9]#[C:10][CH3:11])[CH3:8])=[O:5].[Cl:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Cl:13][CH:3]([S:2][CH3:1])[C:4]([NH:6][C:7]([CH3:12])([C:9]#[C:10][CH3:11])[CH3:8])=[O:5]

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 860149882-(methylthio)-N-(2-methylpent-3-yn-2-yl)acetamide

Produkt 1

HCID 866108822-chloro-2-methylthio-N-(2-methylpent-3-yn-2-yl)acetamideAusbeute 143,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

The product of Step 1 (0.824 g) was dissolved in carbon tetrachloride (15 ml) with warming. The solution was then cooled to 0° C. and N-chlorosuccinimide (NCS, 0.653 g) was then gradually added and the mixture was stirred at ambient temperature for 2 hours. The reaction mixture was filtered to remove succinimide and the resulting liquid was evaporated to give 2-(chloro)-2-(methylthio)-N-(2-methylpent-3-yn-2-yl) acetamide as a clear oil (1.4 g), which was used without further purification.

Aufarbeitung

  1. temperaturewith warming
  2. filtrationThe reaction mixture was filtered
  3. customto remove succinimide
  4. customthe resulting liquid was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-3e105cff6cdb43a3a46d8d5a2a7bebfa
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067592B2

Notizen zur Reaktion

Wird geladen…