2-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide → HCID 67008363, Verbindung

HRID 563999Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 563999
[Cl:1][C:2]1[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[C:9]2[CH:15]=[CH:14][NH:13][C:10]2=[N:11][CH:12]=1)=[O:5]>C1COCC1.[Pt]>[NH2:20][C:17]1[CH:18]=[CH:19][C:2]([Cl:1])=[C:3]([CH:16]=1)[C:4]([NH:6][C:7]1[CH:8]=[C:9]2[CH:15]=[CH:14][NH:13][C:10]2=[N:11][CH:12]=1)=[O:5]

Komponenten

4

Edukt 1

HCID 670082132-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide

Produkt 1

HCID 67008363HCID 67008363, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3.85 g 2-Chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide in 600 ml THF were hydrogenated over 2.5 g platinum on carbon at atmospheric pressure over night at RT. The catalyst was removed by filtration and the filtrate evaporated. The residue was purified by chromatography on silica eluting first with ethyl acetate and finally ethyl acetate/methanol mixtures.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated
  3. customThe residue was purified by chromatography on silica eluting first with ethyl acetate and finally ethyl acetate/methanol mixtures

Quellen und Nachweise

ORD-Eintrag
ord-d84155c130044411b5548d9df9afe9f9
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067599B2

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