Dichloromethane → 2-Amino-5-bromo-3-chlorobenzoic acid

Beteiligte Stoffe

Reaktionsschritte

To a solution of 2-amino-3-fluorobenzoic acid (10.0 g, 58.5 mmol) in dichloromethane (150 mL) was added N-bromosuccinimide (10.4 g, 58.5 mmol), and the mixture was stirred at room temperature for 2 hours. LCMS showed the reaction was completed. The solid was filtered and washed with dichloromethane (100 mL×3) to give the title compound as a white solid (13.0 g, 89%), which was directly used in the next step without further purification. MS (ES+) C7H5BrClNO2 requires: 249, 251, found: 250, 252 [M+H]+.

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