(2-Amino-5-bromo-3-chlorophenyl)methanol → 2-Amino-5-bromo-3-chlorobenzaldehyde

HRID 56449

Reaktionsgleichung

Reaktionsgleichung von HRID 56449
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

Komponenten

4

Edukt 1

HCID 67080684(2-Amino-5-bromo-3-chlorophenyl)methanol

Produkt 1

HCID 916663072-Amino-5-bromo-3-chlorobenzaldehydeAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 160959Manganese oxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of (2-amino-5-bromo-3-chlorophenyl)methanol (10.0 g, 42.5 mmol) and manganese oxide (21.9 g, 255 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (9.0 g, 91%), which was directly used in the next step without further purification.

Aufarbeitung

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-7e7701d9d0d548799f1f2084c43bcec7
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434700B2

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