N-bromobutanimide → 2-Amino-5-bromo-3-fluorobenzoic acid
Reaktionsgleichung
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]N1C(=O)CCC1=O>ClCCl>[NH2:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 2-amino-3-fluorobenzoic acid (10.85 g, 70 mmol) in dichloromethane (175 mL) was added N-bromosuccinimide (12.46 g, 70 mmol), and the mixture was stirred at room temperature for 2 hours. The precipitate was filtered and washed with dichloromethane (100 mL*3) to give the title compound (12.7 g, 78%) as a grey solid, which was directly used in the next step without further purification. MS (ES+) C7H5BrFNO2 requires: 233, 235, found: 232, 234 [M+H]+.
Aufarbeitung
- filtrationThe precipitate was filtered
- washwashed with dichloromethane (100 mL*3)
Quellen und Nachweise
- ORD-Eintrag
- ord-b4471c6e3f3b489f9ebd1151cd0d9116
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09434700B2
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