(2-Amino-5-bromo-3-fluorophenyl)methanol → 2-Amino-5-bromo-3-fluorobenzaldehyde

HRID 56470

Reaktionsgleichung

Reaktionsgleichung von HRID 56470
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

Komponenten

4

Edukt 1

HCID 54312525(2-Amino-5-bromo-3-fluorophenyl)methanol

Produkt 1

HCID 542514502-Amino-5-bromo-3-fluorobenzaldehydeAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 160959Manganese oxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (13 g, 59.4 mmol) and manganese oxide (31 g, 356.4 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound (11 g, 85%) as a light yellow solid, which was directly used in the next step without further purification.

Aufarbeitung

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-004fce44929f4e97a083ea9f5adc78fc
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434700B2

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