4-Amino-5-pyrimidinecarbonitrile → 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (5-cyanopyrimidin-4-yl)amide

HRID 564733Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 564733
[N+](C1C=CC(O[C:11]([C:13]2[C:14]3[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=3[C:16]([O:19][CH3:20])=[N:17][CH:18]=2)=[O:12])=CC=1)([O-])=O.[NH2:26][C:27]1[C:32]([C:33]#[N:34])=[CH:31][N:30]=[CH:29][N:28]=1>>[C:33]([C:32]1[C:27]([NH:26][C:11]([C:13]2[C:14]3[CH:23]=[C:22]([CH2:24][CH3:25])[O:21][C:15]=3[C:16]([O:19][CH3:20])=[N:17][CH:18]=2)=[O:12])=[N:28][CH:29]=[N:30][CH:31]=1)#[N:34]

Komponenten

3

Edukt 2

HCID 7372084-Amino-5-pyrimidinecarbonitrileHCID 541193452-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester

Produkt 1

HCID 443653302-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (5-cyanopyrimidin-4-yl)amideAusbeute 58,2 %

Versuchsvorschrift

Starting from 2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (200 mg) and 4-aminopyrimidine-5-carbonitrile (84 mg). Purification by trituration with ethyl acetate and methanol gave the title compound (110 mg) as an off white solid.

Aufarbeitung

  1. customPurification by trituration with ethyl acetate and methanol

Quellen und Nachweise

ORD-Eintrag
ord-1f803e18aa6941ada2a94ee8434d3e23
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06169090A

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