Urea → 6-bromo-5-fluoroquinazolin-2(1H)-one
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([CH:8]=O)=[C:6]([F:10])[C:5]([Br:11])=[CH:4][CH:3]=1.[NH2:12][C:13](N)=[O:14]>>[Br:11][C:5]1[C:6]([F:10])=[C:7]2[C:2](=[CH:3][CH:4]=1)[N:1]=[C:13]([OH:14])[N:12]=[CH:8]2Komponenten
3
Reaktionsbedingungen
- Temperatur
- 180 °C
Versuchsvorschrift
A mixture of 6-amino-3-bromo-2-fluorobenzaldehyde (3.0 g, 13.76 mmol) and urea (12.40 g, 206.40 mmol) was heated to 180° C. and stirred for 2 hours. The reaction mixture was cooled to room temperature. The resulting precipitate was collected, washed with water (3×100 mL) and co-evaporated with toluene three times to completely remove the moisture trapped. The title compound (3.3 g, 99%) was obtained as a yellow solid. MS (ES+) C8H4BrFN2O requires: 242, found: 243, 245 [M+H]+.