Triethylamine → 4-morpholino-N-(4-nitrophenoxycarbonyl)aniline

HRID 564811Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 564811
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C.Cl[C:22]([O:24][C:25]1[CH:30]=[CH:29][C:28]([N+:31]([O-:33])=[O:32])=[CH:27][CH:26]=1)=[O:23]>C(Cl)Cl>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:13]=[CH:12][C:10]([NH:11][C:22]([O:24][C:25]3[CH:26]=[CH:27][C:28]([N+:31]([O-:33])=[O:32])=[CH:29][CH:30]=3)=[O:23])=[CH:9][CH:8]=2)[CH2:5][CH2:6]1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 821294-Nitrophenyl chloroformate

Produkt 1

HCID 227075274-morpholino-N-(4-nitrophenoxycarbonyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2.60 g (14.6 mmol) of 4-morpholinoaniline in 20 ml of methylene chloride were added 14.07 ml (105 mmol) of triethylamine and 3.53 g (17.5 mmol) of 4-nitrophenyl chloroformate under ice-cooling, followed by stirring at room temperature for 7 hours. After the solvent was evaporated, water was added to the residue, and the precipitated crystals were collected by filtration, washed water, and dried to give 4-morpholino-N-(4-nitrophenoxycarbonyl)aniline.

Aufarbeitung

  1. temperaturecooling
  2. customAfter the solvent was evaporated
  3. additionwater was added to the residue
  4. filtrationthe precipitated crystals were collected by filtration
  5. washwashed water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0b0958d5bf844fca996bcb494cb7e5e9
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06169088A

Notizen zur Reaktion

Wird geladen…