2,4-Difluorobenzaldehyde → HCID 54311230, Verbindung

HRID 565217Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 565217
[C:1]([CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7])(=[O:4])[CH2:2][CH3:3].[F:16][C:17]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=1[CH:19]=O>C1C=CC=CC=1.C([O-])(=O)C.[NH2+]1CCCCC1>[F:16][C:17]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=1[CH:19]=[C:5]([C:1](=[O:4])[CH2:2][CH3:3])[C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7]

Komponenten

5

Edukt 2

HCID 737702,4-DifluorobenzaldehydeHCID 12425357HCID 12425357, Verbindung

Produkt 1

HCID 54311230HCID 54311230, VerbindungAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3014295Piperidinium acetateKatalysatorHCID 241BenzeneLösungsmittel

Versuchsvorschrift

A solution of benzyl propionylacetate (157 g, 0.758 mol), 2,4-difluorobenzaldehyde (107.65 g, 0.758 mol), and piperidinium acetate (5.49 g, 38 mmol) in benzene (1 L) were stirred at room temperature for 96 h. The mixture was washed with water (2×100 mL), dried (magnesium sulfate) and the solvent evaporated under reduced pressure to yield the product as a pale yellow syrup (251.2 g) which was used in the next step without further purification.

Aufarbeitung

  1. washThe mixture was washed with water (2×100 mL)
  2. dry with materialdried (magnesium sulfate)
  3. customthe solvent evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e6e121c901fb40bc93d2b5e9f258c83b
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06172066B2

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