N,N-Dimethyl-4-nitrobenzylamine → Benzenemethanamine, 4-amino-N,N-dimethyl-

HRID 565840Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 565840
[CH3:1][N:2]([CH3:13])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][CH:5]=1>C(O)C>[NH2:10][C:7]1[CH:6]=[CH:5][C:4]([CH2:3][N:2]([CH3:13])[CH3:1])=[CH:9][CH:8]=1

Komponenten

3

Edukt 1

HCID 278498N,N-Dimethyl-4-nitrobenzylamine

Produkt 1

HCID 308051Benzenemethanamine, 4-amino-N,N-dimethyl-Ausbeute 50,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In ethanol (100 ml) was dissolved dimethyl-4-nitrobenzylamine (20.7 g), and to the mixture was added dried 10% palladium on carbon (1.00 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 20 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was separated and purified with column chromatography (ethyl acetate) to give 4-aminobenzyldimethylamine (8.75 g) as pale yellow oil.

Aufarbeitung

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon (1.00 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated
  5. customThe residue was separated
  6. custompurified with column chromatography (ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-1193b37cfa4b47d1935fa5fae2b6df78
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06172061B2

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