1-[2-(4-Nitrophenyl)ethyl]piperidine → 4-(2-(Piperidin-1-yl)ethyl)aniline

HRID 565844

Reaktionsgleichung

Reaktionsgleichung von HRID 565844
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1

Komponenten

3

Edukt 1

HCID 2205731-[2-(4-Nitrophenyl)ethyl]piperidine

Produkt 1

HCID 107034004-(2-(Piperidin-1-yl)ethyl)anilineAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In ethanol (100 ml) was dissolved 1-[2-(4-nitrophenyl)ethyl]piperidine (24.8 g), and to the mixture was added dried 10% palladium on carbon (1.24 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 86 hours. The palladium was filtered off, and the filtrate was concentrated to give 1-[2-(4-aminophenyl)ethyl]-piperidine (21.7 g) as pale brown oil.

Aufarbeitung

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon (1.24 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-18e902232dcb47e092700ab5db58a929
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06172061B2

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