Methyl iodide → 4-Benzyl-1-methyl-1-[4-[7-(4-methylphenyl)-3,4-dihydronaphthalene-2-carboxamido]benzyl]-piperidinium iodide
Reaktionsgleichung
[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22]([C:24]3[CH2:33][CH2:32][C:31]4[C:26](=[CH:27][C:28]([C:34]5[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=5)=[CH:29][CH:30]=4)[CH:25]=3)=[O:23])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[I:42].[C:43](OCC)(=O)C>CN(C=O)C>[I-:42].[CH2:1]([CH:8]1[CH2:13][CH2:12][N+:11]([CH3:43])([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22]([C:24]3[CH2:33][CH2:32][C:31]4[C:26](=[CH:27][C:28]([C:34]5[CH:35]=[CH:36][C:37]([CH3:40])=[CH:38][CH:39]=5)=[CH:29][CH:30]=4)[CH:25]=3)=[O:23])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In DMF (3ml) was dissolved N-[4-(4-benzyl-piperidino-methyl)-phenyl]-7-(4-methylphenyl)-3,4-dihydro-naphthalene-2-carboxamide (150mg), and to the mixture was added methyl iodide (53 μl). The mixture was stirred at room temperature for 23 hours. To the reaction mixture was added ethyl acetate (100ml), and the resulting precipitate was filtered to give 4-benzyl-1-methyl-1-[4-[7-(4-methyl-phenyl)-3,4-dihydronaphthalene-2-carboxamido]benzyl]-piperidinium iodide (Compound 36) (141mg, ratio of isomers=19:81) as colorless crystals.
Aufarbeitung
- filtrationthe resulting precipitate was filtered
Quellen und Nachweise
- ORD-Eintrag
- ord-7152d68605864498a592b1dd67164e23
- Quelldatensatz
- uspto-grants-2001_01
- Patentnummer
- US06172061B2
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