tert-Butyl 2-bromopropanoate → tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate

Beteiligte Stoffe

Reaktionsschritte

6.0 g (34.5 mmol) of 4-bromopyridin-2(1H)-one and 7.9 g (37.9 mmol) of tert-butyl 2-bromopropanoate (racemate) were reacted according to General Method 4B. After removal of the DMF, the desired product was precipitated with water and then purified further by flash chromatography (silica gel 60, mobile phase: cyclohexane/ethyl acetate mixtures). Yield: 7.4 g (69% of theory)

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