Ethyl benzoylformate → N-(1-benzyl-4-piperidinyl)phenyl-glyoxylic acid amide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Added to 4.28 g of ethyl phenylglyoxylate were 9.12 g of 4-amino-1-benzylpiperidine. The mixture was heated and stirred at 120° C. for 3 hours on an oil bath. Thereafter, ethanol formed was distilled off under reduced pressure, and the residue was purified by column chromatography on silica gel, thereby obtaining 6.3 g (yield: 81.4%) of N-(1-benzyl-4-piperidinyl)phenyl-glyoxylic acid amide.

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