HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium hydride → Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-methylbutanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | Ethyl 2-bromoisovalerate | HCID 79068 | — |
| Edukt | Lithium Bromide | HCID 82050 | — |
| Edukt | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| Produkt | Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-methylbutanoate | HCID 117622680 | — |
Reaktionsschritte
500 mg (2.9 mmol) of 4-bromopyridin-2(1H)-one and 841 mg (4.02 mmol) of ethyl 2-bromo-3-methylbutanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C. Yield: 260 mg (purity 92%, 28% of theory)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09434690B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-c500bff0312245cb8bcb8b8c72a9fb80 |
| Quellennotiz | uspto-grants-2016_09 |