1,2-Dibromoethane → 1-[2-(2-Bromoethoxy)-1-(3-fluorophenyl)ethenyl]-3-fluorobenzene

HRID 566571Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 566571
[F:1][C:2]1[CH:3]=[C:4]([CH:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=2)[CH:9]=[O:10])[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].[Br:20][CH2:21][CH2:22]Br>ClCCl.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.[Cl-].[Na+].O>[Br:20][CH2:21][CH2:22][O:10][CH:9]=[C:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1

Komponenten

7

Edukt 3

HCID 78391,2-DibromoethaneHCID 14798Sodium HydroxideHCID 54068354HCID 54068354, Verbindung

Produkt 1

HCID 106884311-[2-(2-Bromoethoxy)-1-(3-fluorophenyl)ethenyl]-3-fluorobenzeneAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 74236Tetrabutylammonium BromideKatalysatorHCID 6344DichloromethaneLösungsmittel2×HCID 57417360Sodium chloride; waterLösungsmittel

Versuchsvorschrift

bis(3-Fluorophenyl)acetaldehyde (4.82 g, 0.0208 mol) was dissolved in dichloromethane (50 ml) and tetra-n-butylammonium bromide (0.67 g, 0.00208 mol) was added. 12 N sodium hydroxide solution (50 ml) and 1,2-dibromoethane (17.9 ml, 0.208 mol) were introduced and the mixture was stirred vigorously at room temperatue for 20 h. Dichloromethane (100 ml) and saturated brine (50 ml) were added, and the phases were separated. The aqueous phase was extracted further with dichloromethane (50 ml) and the combined dichloromethane extracts were washed with water (2×75 ml) and saturated brine (50 ml). Drying of the dichloromethane solution (Na2SO4) and evaporation provided 1-(2-(2-bromoethoxy)-1-(3-fluoro-phenyl)ethenyl)-3-fluorobenzene as an oil (6.66 g, 95%).

Aufarbeitung

  1. customthe phases were separated
  2. extractionThe aqueous phase was extracted further with dichloromethane (50 ml)
  3. washthe combined dichloromethane extracts were washed with water (2×75 ml) and saturated brine (50 ml)
  4. dry with materialDrying of the dichloromethane solution (Na2SO4) and evaporation

Quellen und Nachweise

ORD-Eintrag
ord-d79a97ebe9fb4db79b7436b0b87b123b
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06174898B1

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