HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 56662Erstellt: 25. Oktober 2026
Sodium hydride → Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoate
https://huagongshe.com/reaction/56662
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | Lithium Bromide | HCID 82050 | — |
| Edukt | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| Edukt | Ethyl 3-cyclopropyl-2-[(methylsulphonyl)oxy]propanoate | HCID 117605475 | — |
| Produkt | Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-cyclopropylpropanoate | HCID 117622870 | — |
Reaktionsschritte
1.02 g (5.87 mmol) of 4-bromopyridin-2(1H)-one and 2.23 g (purity 56%, 5.28 mmol) of ethyl 3-cyclopropyl-2-[(methylsulphonyl)oxy]propanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C (stirred at 65° C. overnight). Yield: 246 mg (13% of theory)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US09434690B2 |
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| Quelldatensatz | uspto-grants-2016_09 |
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| ORD ID | ord-e4b0243d8a54422bb0021d2b39bd193f |
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| Quellennotiz | uspto-grants-2016_09 |
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