Dimethyl Sulfoxide → 3-[2-(Trifluoromethyl)phenoxy]phthaionitrile

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A reaction flask equipped with a cooling tube was loaded with 8.7 g of 3-nitrophthalonitrile, 9.4 g of 2-(trifluoromethyl)phenol, 13.8 g of anhydrous potassium carbonate and 350 ml of dimethyl sulfoxide, and the temperature was raised to 50° C. with stirring under nitrogen flow. After stirring at 50° C. for three hours, the heating was stopped. The reaction liquid was cooled and added into 500 ml of water, and the precipitated crystal was collected and dried to yield 13.5 g of the intended compound.

Herkunft & Nachweise