tert-Butyl 2-bromopropanoate → tert-Butyl 2-[4-(5-chloro-2-cyanophenyl)-5-fluoro-2-oxopyridin-1(2H)-yl]propanoate

HRID 56693

Reaktionsgleichung

Reaktionsgleichung von HRID 56693
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]2[C:15]([F:16])=[CH:14][NH:13][C:12](=[O:17])[CH:11]=2)[CH:3]=1.Br[CH:19]([CH3:27])[C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21]>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]2[C:15]([F:16])=[CH:14][N:13]([CH:19]([CH3:27])[C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C:12](=[O:17])[CH:11]=2)[CH:3]=1

Komponenten

3

Edukt 2

HCID 545327tert-Butyl 2-bromopropanoateHCID 1176048194-Chloro-2-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile

Produkt 1

HCID 117622824tert-Butyl 2-[4-(5-chloro-2-cyanophenyl)-5-fluoro-2-oxopyridin-1(2H)-yl]propanoate

Versuchsvorschrift

126 mg (0.51 mmol) of 4-chloro-2-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile and 1.05 eq. of tert-butyl 2-bromopropanoate (racemate) were reacted according to General Method 4B at 100° C. Yield: 48 mg (25% of theory)

Aufarbeitung

  1. customaccording to General Method 4B at 100° C

Quellen und Nachweise

ORD-Eintrag
ord-50f8ec2c57d24ebe96c2ab1a34fd6682
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434690B2

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