HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Bromopropionic acid → Hydrochloric Acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Bromopropionic acid | HCID 11729 | — |
| Edukt | 4-Chloro-2-(5-chloro-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile | HCID 117605221 | — |
| Produkt | Hydrochloric Acid | HCID 313 | — |
| Produkt | 2-[5-Chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid | HCID 117622549 | — |
Reaktionsschritte
910 mg (purity 57%, 1.96 mmol) of 4-chloro-2-(5-chloro-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A, initially at RT for 2.5 h and then at 45° C. overnight. The desired product was obtained by precipitation with hydrochloric acid. Yield: 1.06 g (purity 78%, quant.)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09434690B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-3bf6cf3c49e5403095b732419e13cb77 |
| Quellennotiz | uspto-grants-2016_09 |