(5-Chloro-2-methoxypyridin-4-yl)boronic acid → 5-Chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-methoxypyridine
Reaktionsgleichung
[Cl:1][C:2]1[C:3](B(O)O)=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Br[C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[CH:21]([F:23])[F:22]>>[Cl:1][C:2]1[C:3]([C:14]2[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=2[CH:21]([F:23])[F:22])=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1Komponenten
3
Versuchsvorschrift
463 mg (purity 93%, 2.3 mmol) of (5-chloro-2-methoxypyridin-4-yl)boronic acid and 515 mg (2.1 mmol) of 2-bromo-4-chloro-1-(difluoromethyl)benzene in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 305 mg (purity 77%, 34% of theory)
Quellen und Nachweise
- ORD-Eintrag
- ord-9f8edd3dd2a2499d8bb12cfe532680b7
- Quelldatensatz
- uspto-grants-2016_09