Pyridinium hydrochloride → 4-(5-Chloro-2-cyanophenyl)-6-oxo-1,6-dihydropyridin-3-carbonitrile

HRID 56713

Reaktionsgleichung

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:18]#[N:19])=[C:6]([C:8]2[CH:13]=[C:12]([O:14]C)[N:11]=[CH:10][C:9]=2[C:16]#[N:17])[CH:7]=1.Cl.[NH+]1C=CC=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:18]#[N:19])=[C:6]([C:8]2[C:9]([C:16]#[N:17])=[CH:10][NH:11][C:12](=[O:14])[CH:13]=2)[CH:7]=1

Komponenten

Edukt 2

HCID 21584435Pyridinium hydrochloride

HCID 1176049104-(5-Chloro-2-cyanophenyl)-6-methoxypyridin-3-carbonitrile

Produkt 1

HCID 1176056654-(5-Chloro-2-cyanophenyl)-6-oxo-1,6-dihydropyridin-3-carbonitrile

Versuchsvorschrift

414 mg (purity 94%, 1.14 mmol) of 4-(5-chloro-2-cyanophenyl)-6-methoxypyridin-3-carbonitrile and pyridinium hydrochloride were reacted according to General Method 3A. Yield: 312 mg (purity 91%, 77% of theory)

Quellen und Nachweise

ORD-Eintrag: ord-286176a007e44eb3b6ad3ebd47ff8491
Quelldatensatz: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09434690B2

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