HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Bromopropionic acid → 2-[4-(5-Chloro-2-cyanophenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Bromopropionic acid | HCID 11729 | — |
| Edukt | 4-(5-Chloro-2-cyanophenyl)-6-oxo-1,6-dihydropyridin-3-carbonitrile | HCID 117605665 | — |
| Produkt | 2-[4-(5-Chloro-2-cyanophenyl)-5-cyano-2-oxopyridin-1(2H)-yl]propanoic acid | HCID 117622765 | — |
Reaktionsschritte
312 mg (purity 91%, 1.11 mmol) of 4-(5-chloro-2-cyanophenyl)-6-oxo-1,6-dihydropyridin-3-carbonitrile and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 45° C. Yield: 240 mg (purity 85%, 56% of theory)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09434690B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-18db1e831c1f4d97889247fdc84cacdc |
| Quellennotiz | uspto-grants-2016_09 |