2-Bromo-4-chlorobenzonitrile → 4-Chloro-2-(2,5-dimethoxypyridin-4-yl)benzonitrile
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:8]=[C:7](B(O)O)[C:6]([O:12][CH3:13])=[CH:5][N:4]=1.Br[C:15]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:16]=1[C:17]#[N:18]>>[Cl:23][C:21]1[CH:22]=[CH:15][C:16]([C:17]#[N:18])=[C:19]([C:7]2[C:6]([O:12][CH3:13])=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=2)[CH:20]=1Komponenten
3
Versuchsvorschrift
7.87 g (purity 95%, 40.86 mmol) of 2,5-dimethoxypyridin-4-ylboronic acid and 8.85 g (40.86 mmol) of 2-bromo-4-chlorobenzonitrile in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 6.23 g (purity 92%, 51% of theory)
Quellen und Nachweise
- ORD-Eintrag
- ord-e22a23f4a69c40a29f6214214a1fd8be
- Quelldatensatz
- uspto-grants-2016_09