2-(2,6-Difluoro-phenyl)-6-nitro-benzo[d][1,3]oxazin-4-one → 6-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

Beteiligte Stoffe

Reaktionsschritte

6-Nitro-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one (50 mg) was dissolved in acetic acid (5 mL) under N2, PtO2 (2.5 mg) was added and the mixture was hydrogenated with H2 gas. Reaction time 2 h. The reaction mixture was filtered through Hyflo®, which was rinsed afterwards with ethyl acetate. The combined organic phases were evaporated to dryness and subsequently treated three times with toluene followed by evaporation.

Herkunft & Nachweise