1-Propanol → Sampatrilat

HRID 567942Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 567942
O.[C:2]([C@H:5]([CH2:27][NH:28][C:29](=[O:41])[C@H:30]([CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH2:6][C:7]1([C:12]([NH:14][C@H:15]([C:24]([OH:26])=[O:25])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]1)([OH:4])=[O:3].C(O)CC>C(#N)C>[C:2]([C@H:5]([CH2:27][NH:28][C:29](=[O:41])[C@H:30]([CH2:36][CH2:37][CH2:38][CH2:39][NH2:40])[NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH2:6][C:7]1([C:12]([NH:14][C@H:15]([C:24]([OH:26])=[O:25])[CH2:16][C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]1)([OH:4])=[O:3]

Komponenten

4

Edukt 2

HCID 10311-PropanolHCID 86756334HCID 86756334, Verbindung

Produkt 1

HCID 6324648Sampatrilat

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

(S,S,S)-N-(1-[2-Carboxy-3-(N2-mesyllysylamino)propyl]-1-cyclopentylcarbonyl)tyrosine hydrate (the δ-form, see Preparation 2) (1.0 g) was stirred with either n-propanol or acetonitrile (10 ml) for 24 hours at room temperature. In each case the white solid obtained was collected by filtration and dried to provide the title compound, m.p. 172-176° C.

Aufarbeitung

  1. customPreparation 2) (1.0 g)
  2. customIn each case the white solid obtained
  3. filtrationwas collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6b682b1f5ed94bd4b8562c1aa519786b
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06180665B2

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